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Quorum sensing in gram negative bacteria

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It has become increasingly and widely recognised that bacteria do not live as isolated entities but instead exist as communities that exploit elaborate systems of intercellular communication to facilitate their adaptation to changing environmental conditions. A well-characterised example of such intercellular communication is quorum sensing. | Turk J Biol 27 (2003) 85-93 © TÜB‹TAK Quorum Sensing in Gram-Negative Bacteria Gülgün BOfiGELMEZ-TINAZ Department of Biology, Faculty of Art and Sciences, Süleyman Demirel University, Isparta - TURKEY Received: 15.11.2002 Abstract: It has become increasingly and widely recognised that bacteria do not live as isolated entities but instead exist as communities that exploit elaborate systems of intercellular communication to facilitate their adaptation to changing environmental conditions. A well-characterised example of such intercellular communication is quorum sensing. Quorum sensing depends on the production of diffusible signal molecules termed autoinducers or pheromones, which enable a bacterium to monitor its own cell population density. A variety of physiological processes in a range of bacterial species is regulated by quorum sensing. Examples include bioluminescence, antibiotic biosynthesis, swarming, biofilm differentiation, conjugation and the production of virulence determinants in animal, fish and plant pathogens. The best studied common signalling molecules found in Gram-negative bacteria are N-acyl derivatives of homoserine lactone (acyl HSLs). In this paper, the current state of research concerning acyl HSL-mediated quorum sensing in Gram-negative bacteria is reviewed. Key Words: Quorum sensing, acyl homoserine lactones, bacterial signalling, gene expression Gram-Negatif Bakterilerde Çevreyi Alg›lama Özet: Bakterilerin izole varl›klar olarak yaflamad›klar›, de¤iflen ortam koflullar›na uyumlar›n› kolaylaflt›rmak için karmafl›k hücreler aras› haberleflme sistemleri kullanan toplukluklar halinde bulunduklar› giderek artan bir yayg›nl›kla kabul edilmektedir. Bu tip hücreler aras› haberleflmenin iyi karakterize edilmifl bir örne¤i, çevreyi alg›lamad›r. Çevreyi alg›lama, bir bakteriye kendi hücre populasyon yo¤unlu¤unu izlemesine olanak veren autoinducer veya feromon olarak adland›r›lan sinyal moleküllerinin üretimine ba¤›ml›d›r. De¤iflik bakteri .