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Long- term survival of women with breast cancer in biomarker context

Premenopausal women had a higher survival rate than postmenopausal patients in groups treated by endocrine therapy or chemotherapy. Postmenopausal women had lower levels of survival than premenopausal women. This might be attributable to more poor prognostic factors in postmenopausal women. The cancer-specific survival in the present study was comparable to that for patients from other Asian and Western countries. | JOURNAL OF MEDICAL RESEARCH LONG-TERM SURVIVAL OF WOMEN WITH BREAST CANCER IN BIOMARKER CONTEXT Vu Hong Thang1,2, Tran Van Thuan1,2, Ta Thanh Van2, Lambert Skoog3 ¹National Cancer Hospital, Vietnam ²Hanoi Medical University, Vietnam 3 Karolinska University Hospital, Solna, Stockholm, Sweden Little is known about breast cancer in Vietnamese women. The aim of this study was to examine the correlation of prognostic factors with relative survival of Vietnamese women afflicted by breast cancer treated at the National Cancer Hospital in Hanoi, Vietnam. We recruited 248 women with operable breast cancer treated with surgery and adjuvant therapy. Tumor tissue samples were stained by a range of immunohistochemically approaches and analyzed for the hormone receptors, HER2 gene amplification status. The Cox model was used to determine the relationship between survival and prognostic treatment factors. The disease-free survival rate, overall survival rate and cancer-specific survival rate were 75.8%, 80.6%, and 86.4%, respectively, at 5 years and 62.3%, 68.1%, 78.9%, respectively, at 9 years. Women with poor prognostic factors (e.g., advanced clinical stage, high tumor grade, progesterone receptor (PgR) negativity, HER2 amplification) had significantly lower survival rates. Postmenopausal women had significantly lower survival rates as compared to premenopausal women when analyzed by univariate analysis (HR = 0.6, 95% CI: 0.38 - 0.95, p = 0.029). However, these comparisons were not statistically significant when subjected to a multivariable analysis (HR = 0.67, 95%CI: 0.41 - 1.08, p = 0.1). Premenopausal women had a higher survival rate than postmenopausal patients in groups treated by endocrine therapy or chemotherapy. Postmenopausal women had lower levels of survival than premenopausal women. This might be attributable to more poor prognostic factors in postmenopausal women. The cancer-specific survival in the present study was comparable to that for patients from other .