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IFN-DC loaded with autophagosomes containing virus antigen is highly efficient in inducing virus specific human T-cells

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Autophagy plays a critical role in the regulation of innate and adaptive immune responses to pathogens and tumors. A previous study utilized proteasome and lysosome inhibitors to form autophagosomes (DRibbles) and the effect of dendritic cells (DCs) loaded with DRibbles in activating antigen-specific T cells has been demonstrated in a mouse experiment and human IL-4-DC. | IFN-DC loaded with autophagosomes containing virus antigen is highly efficient in inducing virus specific human T-cells