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PM2.5 upregulates microRNA-146a-3p and induces M1 polarization in RAW264.7 cells by targeting sirtuin1

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Fine particulate matter (PM2.5) exposure is proved to be associated with illnesses, but the mechanism is not clear. Potential effects of PM2.5 on innate immunity have become a hotspot recently. Confronting PM2.5, macrophages are able to be activated and induce inflammatory responses. Whether PM2.5 exposure affects macrophage polarization and associated mechanisms remains to be further explored. | PM2.5 upregulates microRNA-146a-3p and induces M1 polarization in RAW264.7 cells by targeting sirtuin1