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Association of toll-like receptor 4 + 3725G/C polymorphism in Egyptian breast cancer atients

The activation of Toll-like receptor 4 (TLR4) may be an important event in the immune evasion of tumor cells. TLR4 polymorphisms in breast cancer patients have recently attracted great interest. However, there has been little research on the association between the TLR4 +3725G/C polymorphism and the risk of breast cancer. This study aimed to investigate the frequency of TLR4 +3725G/C gene polymorphism in Egyptian breast cancer patients in order to evaluate its prognostic role in this malignancy. This study was conducted on 75 newly diagnosed breast cancer female patients and 25 apparently healthy control females. Genotyping of TLR4 +3725G/C polymorphism was performed by PCR/RFLP. The present study revealed that the frequencies of GC and CC genotypes of TLR4 +3725G/C polymorphism (P = 0.018) and TLR4 +3725C allele frequency (P=0.003) were significantly higher in breast cancer cases than controls. | Association of toll-like receptor 4 + 3725G/C polymorphism in Egyptian breast cancer atients