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A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria

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Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy including an open-label, randomized controlled trial (RCT) comparing eLVT to phenobarbital. | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria

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