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Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time – An RCT: A multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success

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The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20–50%) rates. Lumbar puncture (LP) remains essential to the diagnosis of meningitis. Though LP is a common procedure in neonates, success rates are lower (50–60%) than in other patient populations. | Study protocol NeoCLEAR Neonatal Champagne Lumbar punctures Every time An RCT A multicentre randomised controlled 2 2 factorial trial to investigate techniques to increase lumbar puncture success

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