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Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells

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Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system. As dependence on iron is a key feature of tumor cells, using chelators to reduce iron represents an opportunity to improve conventional GBM therapies. |

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