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Cross-talk between the Tissue Factor/ coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer

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Tissue Factor (TF) forms a proteolytically active complex together with coagulation factor VIIa (FVIIa) and functions as the trigger of blood coagulation or alternatively activates cell signaling. We recently described that EphA2 of the Eph tyrosine kinase receptor family is cleaved directly by the TF/FVIIa complex. |

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