Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

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Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

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Personalised medicine and targeted therapy have revolutionised cancer treatment. However, most patients develop drug resistance and relapse after showing an initial treatment response. Two theories have been postulated; either secondary resistance mutations develop de novo during therapy by mutagenesis or they are present in minor subclones prior to therapy. |

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Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

Characterization and remediation of sample index swaps by non-redundant dual indexing on massively parallel sequencing platforms

Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index crosstalk and significantly improve sensitivity of massively parallel sequencing

TIA: Algorithms for development of identity-linked SNP islands for analysis by massively parallel DNA sequencing

FAVR (Filtering and Annotation of Variants that are Rare): Methods to facilitate the analysis of rare germline genetic variants from massively parallel sequencing datasets

Comparison of tumor mutation burden of 300 various non-Hodgkin lymphomas using panel based massively parallel sequencing

The applications of massive parallel sequencing (next-generation sequencing) in research and molecular diagnosis of human genetic diseases

A new massively parallel nanoball sequencing platform for whole exome research

Reliable multiplex sequencing with rare index mis-assignment on DNB-based NGS platform

ATRAM - automated target restricted assembly method: A fast method for assembling loci across divergent taxa from next-generation sequencing data

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort

Đang chuẩn bị liên kết để tải về tài liệu: Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

Characterization and remediation of sample index swaps by non-redundant dual indexing on massively parallel sequencing platforms

Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index crosstalk and significantly improve sensitivity of massively parallel sequencing

TIA: Algorithms for development of identity-linked SNP islands for analysis by massively parallel DNA sequencing

FAVR (Filtering and Annotation of Variants that are Rare): Methods to facilitate the analysis of rare germline genetic variants from massively parallel sequencing datasets

Comparison of tumor mutation burden of 300 various non-Hodgkin lymphomas using panel based massively parallel sequencing

The applications of massive parallel sequencing (next-generation sequencing) in research and molecular diagnosis of human genetic diseases

A new massively parallel nanoball sequencing platform for whole exome research

Reliable multiplex sequencing with rare index mis-assignment on DNB-based NGS platform

ATRAM - automated target restricted assembly method: A fast method for assembling loci across divergent taxa from next-generation sequencing data

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort

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Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy