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Cytotoxic activity of paramignya trimera (OLIV.) guillaum plant extracts and their volatile chemical constituents

From Paramignya trimera plants that were collected in the Hon Heo Commune (Khanh Hoa Province, November 2013), n-hexane extracts of its stem bark and leaves was obtained which showed moderate cytotoxic activity towards KB, Hep-G2, Lu and MCF7 cell lines (with IC50 values ranging from 5.7 to 30.89 µg/mL). | JOURNAL OF SCIENCE OF HNUE Chemical and Biological Sci. 2014 Vol. 59 No. 9 pp. 11-16 This paper is available online at http stdb.hnue.edu.vn CYTOTOXIC ACTIVITY OF Paramignya trimera OLIV. GUILLAUM PLANT EXTRACTS AND THEIR VOLATILE CHEMICAL CONSTITUENTS Nguyen Thi Thanh Hoa1 Souknaly Thoumma1 2 Lam Thi Hai Yen1 and Pham Huu Dien1 1 Faculty of Chemisty Hanoi National University of Education 2 Faculty of Education National University of Laos Abstract. From Paramignya trimera plants that were collected in the Hon Heo Commune Khanh Hoa Province November 2013 n-hexane extracts of its stem bark and leaves was obtained which showed moderate cytotoxic activity towards KB Hep-G2 Lu and MCF7 cell lines with IC50 values ranging from 5.7 to 30.89 µg mL . A GC-MS analysis of the volatile plant components showed that esters saturated alcohols and sesquiterpenes including β-farnesene and α-gurjunene are the major compounds. Keywords Paramignya trimera cytotoxicity volatile compounds. 1. Introduction The genus Paramignya family Rutaceae subfamily Aurantioideae consists of fifteen species and two subspecies that are scattered across S.E. Asia from India to Indonesia and the Philippines 7 . Plants of the genus are a woody climber growing at low or moderate altitudes and they are used as medicinal plants in many countries including Sri Lanka India and the Philippines. In Vietnam three species have been found P. amata P. monophylla and P. trimera all of which are widely distributed from Da Nang to Khanh Hoa Province 1 2 . P. trimera Xao tam phan was recently reported to show hepatoprotective and cytotoxic activity towards the five cancer cell lines Hep-G2 HTC116 MDA MB231 DVCAR-8 and Hela 3 . Studies on the chemical constituents of the genus Paramignya are very limited. Scientists from Sri Lanka found that the fruit of P. monophylla contained triterpenes of the tirucallane type including flindissone and four pyranocoumarins including poncitrin and nordentatin are present in the stem .