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Prevalence of extended spectrum beta- lactamase producers among various clinical samples in a Tertiary Care Hospital: Kurnool district, India

Extended spectrum beta lactamase producers are posing a major obstacle in the therapeutic outcome of patients. They cause enzymatic hydrolysis of the beta lactum ring, resulting in resistance to penicillins and cephalosporins. The rise in ESBL producers results in prolonged treatment which leads to increased hospital stay and financial burden on the patient. It is necessary for all the hospitals to monitor ESBL producers to formulate preventive and therapeutic measures accordingly. The study was conducted in a tertiary care hospital during the period from December 2015 to November 2016. A total of 500 isolates from Enterobacteriaceae which included 400 Escherichia coli and 100 Klebsiella species isolates were processed. ESBL producers were detected by phenotypic screening and confirmatory methods which included double disc synergy method, Cephalosporin Clavulanate combination disc. |