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Summary of Biology doctoral thesis: Study on polymorphisms mutations of CYP2C29, CYP2C19, CYP3A5 và CYP2D6 cytochrome P450 in Kinh vietnamese

Establish the genetic variants database of 04 genes CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in Kinh Vietnamese. Identification of genotype and allele frequencies of 04 genes CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in Kinh Vietnamese. Perform in silico functional analysis of novel variants. | MINISTRY OF EDUCATION VIETNAM ACADEMY AND TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ---------------------------- Vu Phuong Nhung STUDY ON POLYMORPHISMS MUTATIONS OF CYP2C9 CYP2C19 CYP3A5 AND CYP2D6 CYTOCHROME P450 IN KINH VIETNAMESE Major Biotechnology Code 9420201 SUMMARY OF BIOLOGY DOCTORAL THESIS Hanoi - 2020 The thesis has been completed at Graduate University of Science and Technology - Vietnam Academy of Science and Technology. Supervisor 1 Dr. Nguyen Hai Ha Supervisor 2 Prof. Dr. Nong Van Hai Reviewer 1 Reviewer 2 Reviewer 3 The thesis will be defended at the Board of Examiners of Graduate University of Science and Technology-Vietnam Academy of Science and Technology at .on . The thesis can be referred at - Library of Graduate University of Science and Technology - National Library of Vietnam INTRODUCTION 1.The necessity of research Interindividual differences in drug response are unavoidable during treatments including adverse drug reactions ADRs . ADRs are one of the main cause of hospitalizations which could be lethal in some cases. Since 2009 the Clinical Pharmacogenetics Implementation Consortium CPIC has been providing information on genetic testing that can be applied in drug regimen optimization. For some gene-drug pairs the CPIC has also given specific dosage instructions. The four genes CYP2C9 CYP2C19 CYP2D6 and CYP3A5 are highly polymorphic CYP450 genes which polymorphism could lead to ability to metabolize specific drugs very differently in patients. Up to now the understanding of genetic diversity of the CYP450 genes involved in drug metabolism in Vietnam is still limited. Given that pharmacogenetics plays a significant role in drug metabolism and drug interactions in the clinic it is noteworthy to pay more attention in this field. This study focuses on the detection of known alleles as well as the identification of novel allele in Kinh Vietnamese. Data obtained from the study would provide scientific .