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NUCLIZE for quantifying epigenome: Generating histone modification data at single-nucleosome resolution using genuine nucleosome positions

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Defining histone modification at single-nucleosome resolution provides accurate epigenomic information in individual nucleosomes. However, most of histone modification data deposited in current databases, such as ENCODE and Roadmap, have low resolution with peaks of several kilo-base pairs (kb), which due to the technical defects of regular ChIP-Seq technology. |