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Biotinylated N,N’-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

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Biotinylated analogs of drug candidates provide useful tools for studying the drug–target protein interactions. Polyhalogenated N,N’diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N’-diarylureas were synthesized and evaluated in AMPK-activation studies. |