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Study protocol: Understanding the pathophysiologic mechanisms underlying delirium in older people undergoing hip fracture surgery

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Postoperative delirium (POD) is a common complication of older people undergoing hip fracture surgery, which negatively afects clinical- and healthcare-related outcomes. Unfortunately, POD pathophysiology is still largely unknown, despite previous studies showing that neuroinfammation, neuroendocrine dysfunction, increased reactive oxidative stress (ROS), and endothelial dysfunctions may be involved. |

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