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An observational study protocol to explore loneliness and systemic inflammation in an older adult population with chronic venous leg ulcers

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Chronic venous leg ulcers (CVLUs) are the most common type of lower extremity wound. Even when treated with evidenced-based care, 30–50% of CVLUs fail to heal. A specific gap exists about the association between psychosocial stressors, particularly loneliness, and biomarkers of inflammation and immunity. |

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