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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 47)

Introduction: Boric acid and borax (sodium tetraborate) had been widely used as antiseptics (preservatives) and/or ethical drugs; however, by reevaluation made in Japan, 1985, the questionability was raised on their effectiveness. Nowadays, they are being permitted to be used only for washing or disinfection of the eye as ethical drugs. In recent year, boric acid has been widely used as a household insecticide especially for cockroaches (called “boric acid ball”), resulting in the increase of boric acid poisoning cases. The boric acid ball is a toxic bait for cockroaches; its toxicity is slow-acting, but fatal for the insects. Various types. | II.5.5 Boric a cid by Shinichi Suzuki Introduction Boric acid and borax sodium tetraborate had been widely used as antiseptics preservatives and or ethical drugs however by reevaluation made in Japan 1985 the questionability was raised on their effectiveness. Nowadays they are being permitted to be used only for washing or disinfection of the eye as ethical drugs. In recent year boric acid has been widely used as a household insecticide especially for cockroaches called boric acid ball resulting in the increase of boric acid poisoning cases. The boric acid ball is a toxic bait for cockroaches its toxicity is slow-acting but fatal for the insects. Various types of boric acid ball products are commercially available but it can be handmade at home very easily. As an attractant material for cockroaches crushed onions are being usually added to boric acid. Because of wide availability of the boric acid balls accidental intake of them by infants can occur frequently. As poisoning symptoms of boric acid nausea vomiting diarrhea and bleeding can be mentioned. When a relatively large amount of boric acid is ingested by an infant there is a possibility of fatality. In Japanese trials only with the presence of a toxic substance in a vomitus it is difficult to prove that the toxic substance is causative of a poisoning case namely it does not verify the intake of the poison by the victim. Therefore in Japanese law it is essential to verify the presence of a poison in blood urine and or stomach contents not vomitus . In this chapter the methods for analysis of boric acid in blood urine and stomach contents by spectrophotometry and HPLC are described. Spectrophotometric analysis 1 2 Reagents and their preparation Boric acid and borax can be obtained from Sigma St. Louis MO USA . Curcumin solution 0.1 g curcumin Sigma is dissolved in purified water to prepare 100 mL solution. 2-Ethyl-1 3-hexan ediol solution 10 mL of 2-ethyl-1 3-hexan ediol Aldrich Milwaukee WI USA is dissolved in