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Mechanisms

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Tài liệu tham khảo chuyên đề sinh học bằng tiếng Anh | 2 Mechanisms Bruce A. Palfey CONTENTS 2.1 Introduction 2.2 Basic Concepts 2.2.1 Thermodynamics 2.2.2 Transition-State Theory 2.3 Catalytic Strategies. 2.3.1 Change of Mechanism 2.3.2 Propinquity 2.3.3 Transition-State Binding by Enzymes 2.4 Catalytic Tactics and Intermolecular Forces 2.4.1 Stereoelectronic Controls 2.4.2 van der Waals Interactions 2.4.3 Hydrogen Bonds 2.4.4 Acid Base Catalysis 2.4.5 Electrostatics 2.4.6 Desolvation 2.4.7 Nucleophilic Catalysis 2.4.8 Electrophilic Catalysis 2.4.9 Redox Catalysis 2.4.10 Quantum Mechanical Tunneling and Protein Dynamics Further Reading 2.5 Cytochrome P450 Example W Edward Lindup and Neil R. Kitteringham 2.5.1 Introduction 2.5.2 Background and Historical Context 2.5.3 Chemistry Biochemistry and Molecular Biology of Cytochrome P450 2.5.3.1 Mechanism of Action 2.5.3.2 Biochemistry of Cytochrome P450 Enzymes 2.5.3.3 Molecular Aspects of the Cytochrome P450 Supergene Family 2.5.4 Regulation of the Cytochrome P450 Enzyme System 2.5.4.1 Induction 2.5.4.2 Enzyme Inhibition 2.5.5 P450 and Therapeutic Response 2005 by CRC Press 2.5.6 P450 and Drug Toxicity 2.5.6.1 Liver Damage 2.5.6.2 Kidney Damage 2.5.7 P450 and Disease 2.5.8 Conclusions Further Reading 2.6 Carbonic Anhydrase Example Claudiu T. Supuran Andrea Scozzafava and Angela Casini 2.6.1 Introduction 2.6.2 Mechanism References 2.7 Proteases Example André J. Niestroj and Hans-Ulrich Demuth 2.7.1 Introduction 2.7.1.1 Characterization of Proteases 2.7.1.2 Specificity of Proteases and Spacial Features of the Active Site 2.7.2 Determination of the Structure of Proteases 2.7.2.1 Initial Analytical Methods for the Characterization of Proteases 2.7.3 General Models of the Architecture of the Active Site 2.7.4 Evolutionary Aspects 2.7.5 Examples of Different Architectures of Proteases 2.7.5.1 Covalent Catalysis Cysteine Proteases 2.7.5.2 Catalytic Triad Cys His Asn Asp 2.7.5.3. Covalent Catalysis Serine Proteases 2.7.5.4 Covalent Catalysis Cysteine Serine or Threonine as .