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Polyme phân hủy sinh học từ Xylitol

Lần đầu tiên ở Việt Nam, Viện Hóa học Công nghiệp (Viện Khoa học và Công nghệ Việt Nam) đã nghiên cứu, chế tạo và ứng dụng thành công vật liệu polyme phân hủy sinh học không gây ô nhiễm môi trường. | ADVANCED. MATERIALS DOI 10.1002 adma.200702377 Biodegradable Xylitol-Based Polymers By Joost P. Bruggeman Christopher J. Bettinger Christiaan L.E. Nijst Daniels. Kohane and Robert Langer COMMUNICATION Synthetic biodegradable polymers have made a considerable impact in various fields of biomedical engineering such as drug delivery and tissue engineering. The design of synthetic biodegradable polymers for bioengineering purposes is challenging because of the application-specific constraints on the physical properties including mechanical compliance and degradation rates and the need for biocompatibility and low cytotoxicity. 1 The monomer selection frequently limits the range of required material properties. Our goal was to design a class of synthetic biopolymers based on a monomer that possesses a wide range of properties that are biologically relevant. This monomer ideally should be 1 multifunctional to allow the formation of randomly crosslinked networks and a wide range of crosslinking densities 2 nontoxic 3 endogenous to the human metabolic system 4 FDA approved and 5 preferably inexpensive. We chose xylitol as it meets these criteria. We hypothesized that biodegradable polyesters could be obtained through copolymerization reactions with polycarboxylic acids the hydration of such biodegradable polymers could be controlled by tuning the different compositions and stoichiometry of the reacting monomer. Here we describe xylitol-based polymers that realize this design. Polycondensation of xylitol with watersoluble citric acid yielded biodegradable water-soluble polymers. Acrylation of this polymer resulted in an elastomeric Prof. R. Langer Dr. J. P. Bruggeman C. L. E. Nijst Department of Chemical Engineering Massachusetts Institute ofTechnology Cambridge MA 02139 USA E-mail rlanger@mit.edu Dr. J. P. Bruggeman Department of Plastic and Reconstructive Surgery Erasmus Medical Center Erasmus University Rotterdam 3015 CE Rotterdam The Netherlands Dr. C. J. Bettinger .