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Báo cáo sinh học: "TBP2 is a general transcription factor specialized for female germ cells"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: TBP2 is a general transcription factor specialized for female germ cells. | Journal of Biology Minireview TBP2 is a general transcription factor specialized for female germ cells Ferenc Muller and László Torat Addresses Department of Medical and Molecular Genetics School of Clinical and Experimental Medicine College of Medical and Dental Sciences University of Birmingham Birmingham B15 2TT UK. Department of Functional Genomics Institut de Génétique et de Biologie Moléculaire et Cellulaire IGbMc UmR 7104 CNRS UdS INSErM U964 BP 10142 F-67404 Illkirch Cedex France. Correspondence Ferenc Muller. Email f.mueller@bham.ac.uk. László Tora. Email laszlo@igbmc.u-strasbg.fr Abstract The complexity of the core promoter transcription machinery has emerged as an additional level of transcription regulation that is used during vertebrate development. Recent studies including one published in BMC Biology provide mechanistic insights into how the TATA binding protein TBP and its vertebrate-specific paralog TBP2 TRF3 switch function during the transition from the oocyte to the embryo. See research article http www.biomedcentral.com 1741-7007 7Z45 Regulation of initiation of transcription by RNA polymerase II Pol II is central to any developmental process. A key regulatory step in eukaryotic transcription initiation is the assembly of basal transcription apparatus at the core promoter. This regulatory step has been brought into the spotlight by the discovery of multiple promoter binding factors that assemble into different basal transcription factor complexes. These complexes have to be matched in the future to the diversity of core promoter types and features 1 . This apparent diversity points towards a dynamic regulatory role for this machinery 1 which is very poorly understood. The preinitiation complex includes the core promoter Pol II and the general transcription factors TFIIA B D E F and H. Originally the core promoter recognition factor TFIID which is composed of TATA-binding protein TBP and 14 TBP-associated factors TAFs was thought to be .