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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis) | J. Vet. Sci. 2001 2 2 103-109 OURNAL OF Veterinary Science The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo Bubalus bubalis W. C. Davis A. M. Khalid1 M. J. Hamilton J. S. Ahn Y. H. Park2 and G. H. Cantor Department of Veterinary Microbiology and Pathology College of Veterinary Medicine Washington State University Pullman WA 99164-7040 USA 1 Department of Microbiology Moshtohor Zagazig University Benha Branch Kalioba Egypt Department of Microbiology College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Suwon 441-744 Korea One of the major difficulties in studying the mechanisms of host defense in economically important species indigenous to Asia and the Middle East is the lack of monoclonal antibody mAb reagents that define the immune systems of species other than cattle goats sheep and pigs. One strategy that could obviate this problem at minimal cost is to identify existing mAbs that recognize conserved epitopes on orthologous major histocompatibility complex MHC and leukocyte differentiation molecules. To explore the potential of this approach we screened a large set of mAbs that recognize bovine MHC class I and II molecules and leukocyte differentiation molecules to identify mAbs that react with orthologous molecules in water buffalo. One hundred thirty eight were found that recognize conserved determinants on orthologous molecules. In addition to identifying a useful set of reagents the study has provided insight into the composition of the immune system of the water buffalo Bubalus bubalis . Key words Water buffalo Bubalus bubalus monoclonal antibodies leukocyte differentiation molecules major histocompatibility complex Introduction The water buffalo Bubalus bubalis is an essential component of Asian agriculture representing over one quarter of all domestic Asian bovids 11 . In some nations the majority of domestic bovids are water buffalo Philippines 63.0 Laos .