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Báo cáo khoa học: "Immunohistochemical study of caveolin-1 and -2 in the rat retina"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunohistochemical study of caveolin-1 and -2 in the rat retina | J. Vet. Set. 2006 7 2 101-104 JOURNAL OF Veterinary Science Immunohistochemical study of caveolin-1 and -2 in the rat retina Heechul Kim1 Taeki Lee1 Jeeyoung Lee1 Mee hl ng Ahn1 Changiong Moon1 My II ng Bok Wie2 Taekyun Shin1 z z V cs z V cs z CSkF cs z V cs z V department of Veterinary Medicine Cheju National University Jeju 690-756 Korea department of Veterinary Medicine Kangwon National University Chunchon 200-701 Korea The expression of caveolin-1 and -2 in the retina was examined Western blot analysis showed that both were present. Immunohistochemistry indicated that caveolin-1 was expressed in the majority of retinal layers including the ganglion cell layer inner plexiform layer outer plcxiform layer and in the vascular endothelial cells of the retina. Caveolin-2 was primarily immunostained in the vessels but in a few other elements as well. This is the first demonstration of caveolin differential expression in the retina of rats and suggests that caveolin plays an important role in signal transduction in glial cells and neuronal cells. Key words caveolin immunohistochemistry rat retina Introduction Caveolin has been shown to be involved in many signal transduction mechanisms including phosphorylation by protein kinases and signaling by G-proteins 8 . Caveolin is also known as a cholesterol-binding membrane protein involved in cellular cholesterol transport and homeostasis 3 5 . In addition caveolin seems to be related to caveolae formation where it plays an important role in the specific localization of proteins and other components involved in signal transduction 4 Three isotypes of the protein have been identified caveolin-1 -2 and -3 both caveolin-1 and caveolin-2 are abundantly expressed in a variety of tissues including brain 6 and heart 15 . Because signal transduction and lipid metabolism are central to the function of nervous tissues recent studies have focused on the expression of caveolins in the nervous system. Normal brain tissue has been .