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Báo cáo khoa học: "Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves | J. Vet. Sci. 2007 8 1 21-25 JOURNAL OF Veterinary Science Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves Neetu Rajput Vinod K. Dumka Harpal s. Sandhu Department of Pharmacology and Toxicology College cf Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University Ludhiana-141004 India We investigated the disposition kinetics and urinary excretion of cefpfrome in buffalo calves after a single intravenous administration of 10 mg kg. Also an appropriate dosage regimen was calculated. At 1 min after injection the concentration of cefpirome in the plasma was 57.4 0.72 pg ml which declined to 0.22 0.01 pg ml at 24 h. The cefpirome was rapidly distributed from the blood to the tissue compartment as shown by the high distribution coefficient values 8.67 0.46 h and by the drug s rate of transfer constant from the central to the peripheral compartment K12 4.94 0.31 h . The elimination halflife and the volume of distribution were 2.14 0.02 h and 0.42 0.005 l kg respectively. Once the distribution equilibrium was reached between the tissues and plasma the total body clearance C1B and the ratio of the drug present in the peripheral to the central compartment T P ratio were 0.14 0.002 1 kg h and 1.73 0.06 respectively. Based on the pharmacokinetic parameters we obtained an appropriate intravenous cefpirome dosage regimen for treating ccfpiromc-sensitive bacteria in buffalo calves would be 8.0mg kg repeated at 12 h intervals for 5 days or until persistence of the bacterial infection occurred. Key words buffalo cefpirome cephalosporins dosage pharmacokinetics Introduction Ce f pirome is a cephalosporin that was recently introduced and is frequently used for empirical therapy in severely ill patients in the intensive care oncology and transplantation units 20 . It has potent bactericidal activity against a broad range of gram-negative and gram-positive organisms including Pseudomonas aeruginosa and methicillin .