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Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Effect of 1,25-dihydroxy-vitamin D3 in experimental sepsis. | Int. J. Med. Sci. 2007 4 190 Research Paper International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2007 4 4 190-195 Ivyspring International Publisher. All rights reserved Effect of 1 25-dihydroxy-vitamin D3 in experimental sepsis Soren Moller1 Finn Laigaard1 Klaus Olgaard2 Claus Hemmingsen 1 1. Department of Anaesthesiology Frederiksberg Hospital University of Copenhagen Denmark 2. Department of Nephrology Rigshospitalet University of Copenhagen Denmark Correspondence to Claus Hemmingsen MD DMSc Department of Anaesthesiology Frederiksberg Hospital Nordre Fasanvej 57 DK-2000 Copenhagen Frederiksberg Denmark. Phone 45 3816 3310 E-mail clhe@dadlnet.dk Received 2007.02.27 Accepted 2007.07.09 Published 2007.07.10 Background In addition to the regulation of calcium homeostasis vitamin D affects the cellular immune system targets the TNF-a pathway and increases vasoconstrictor response to angiotensin II. We therefore examined the effect of 1 25-dihydroxy-vitamin D3 on coagulation and organ failure in experimental sepsis in the rat. Methods Three series of placebo-controlled studies were conducted. All rats were pre-treated with daily SC injections of 1 25-dihydroxy-vitamin D3 100 ng kg or placebo vehicle for 3 days. In study 1 sepsis was accomplished by abdominal surgery comprising a coecal ligation and puncture with a 1 2 mm needle or sham surgery. In study 2 the rats had a single IP injection of lipopolysaccharide from E. Coli 0111 B4 LPS 8 mg kg or placebo. In study 3 an hour-long IV infusion of LPS 7 mg kg or placebo was given. Results All three models of sepsis showed significant effects on coagulation and liver function with reduced thrombocyte count and prothrombin time together with elevated ALT and bilirubin p 0.05 as compared to controls. In study 1 the vitamin D treated rats maintained normal platelet count whereas the vehicle treated rats showed a significant reduction p 0.05 . This effect of vitamin D on platelets was not found in the .