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Báo cáo y học: " Effect of dose-escalation of 5-fluorouracil on circadian variability of it"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Effect of dose-escalation of 5-fluorouracil on circadian variability of its . | Int. J. Med. Sci. 2010 7 48 International Journal of Medical Sciences 2010 7 1 48-54 Ivyspring International Publisher. All rights reserved Research Paper Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III IVa esophageal squamous cell carcinoma Akiko Kuwahara 1 Motohiro Yamamori 2 Kohshi Nishiguchi 3 4 Tatsuya Okuno 3 Naoko Chayahara 3 Ikuya Miki 3 Takao Tamura 3 Kaori Kadoyama 2 Tsubasa Inokuma 2 Yoshiji Takemoto 2 Tsutomu Nakamura 3 Kazusaburo Kataoka 1 and Toshiyuki Sakaeda 2 3 H 1. School of Pharmacy and Pharmaceutical Sciences Mukogawa Women s University Nishinomiya 663-8179 Japan 2. Graduate School of Pharmaceutical Sciences Kyoto University Kyoto 606-8501 Japan 3. Kobe University Graduate School of Medicine Kobe 650-0017 Japan 4. Faculty of Pharmaceutical Sciences Kyoto Pharmaceutical University Kyoto 607-8414 Japan ISI Corresponding author Toshiyuki Sakaeda Ph.D. Center for Integrative Education of Pharmacy Frontier Frontier Education Center Graduate School of Pharmaceutical Sciences Kyoto University 46-29 Yoshidashimoadachi-cho Sakyo-ku Kyoto 606-8501 Japan. Tel 81-75-753-9560 Fax 81-75-753-4502 E-Mail sakaedat@pharm.kyoto-u.ac.jp Received 2009.10.14 Accepted 2010.01.28 Published 2010.01.31 Abstract Objective The effects of dose-escalation of 5-fluorouracil 5-FU on the clinical outcome and pharmacokinetics of 5-FU were investigated in Japanese patients with Stage III IVa esophageal squamous cell carcinoma. Methods Thirty-five patients with Stage III IVa were enrolled who were treated with a definitive 5-FU cisplatin-based chemoradiotherapy. A course consisted of continuous infusion of 5-FU at 400 mg m2 day the standard dose group N 27 or 500-550 mg m2 day the high dose group N 8 for days 1-5 and 8-1 2 infusion of cisplatin at 40 mg m2 day on days 1 and 8 and radiation at 2 Gy day on days 1 to 5 8 to 12 and 15 to 19 with a second course repeated after a 2-week interval. Plasma .