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Báo cáo y học: "Significance of Conversation between Mast Cells and Nerves"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Significance of Conversation between Mast Cells and Nerves. | Review Article Significance of Conversation between Mast Cells and Nerves Hanneke P. M. van der Kleij MD John Bienenstock CM MD Hon FRCP FRCP C FRSC Abstract More and more studies are demonstrating interactions between the nervous system and the immune system. However the functional relevance of this interaction still remains to be elucidated. Such associations have been found in the intestine between nerves and mast cells as well as between eosinophils and plasma cells. Similar morphologic associations have been demonstrated in the liver mesentery urinary bladder and skin. Unmyelinated axons especially were found to associate with mast cells as well as Langerhans cells in primate as well as murine skin. Although there are several pathways by which immune cells interact with the nervous system the focus in this review will be on the interaction between mast cells and nerves. Functional communication between mast cells and nerves has been shown to occur in a variety of both physiologic and pathologic situations.1 2 Neuronal mechanisms are involved in mast cell activation and mast cells act as principle transducers of information between peripheral nerves and local inflammatory events. Neuropeptides released from autonomic or nonadrenergic non-cholinergic nerves may influence the recruitment proliferation and activation of leukocytes. On the other hand inflammatory cells may modulate the neuronal phenotype and function. Association of Mast Cells and Nerves It is well established that there is an anatomic association between mast cells and nerves in most H. P. M. van der Kleij J. Bienenstock Brain-Body Institute and Department of Pathology and Molecular Medicine St. Joseph s Healthcare Hamilton Ontario and McMaster University Hamilton Ontario Correspondence to John Bienenstock Department of Pathology and Molecular Medicine McMaster University 1200 Main Street West Hamilton Ontario L8N 3Z5 Canada tissues.3-6 In various studies tissue mast cells invariably showed .