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Báo cáo y học: "Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy. | ORIGINAL ARTICLE Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy John Oppenheimer MD Over the past several decades significant advances have been seen in the diagnosis and treatment of asthma. Recent research has focused on potential phenotypic and genotypic predictors of response to therapy. In this review we will examine each of the three major therapeutic classes of asthma therapy focusing on a potential genetic clue to medication response. Key words asthma genetic polymorphisms Our understanding of the pathophysiology and treatment of asthma is quickly advancing. Clinicians have long understood that asthmatic patients response to therapy is quite variable. This means that there are responders and nonresponders to a specific class of asthma therapy. Several recent studies have highlighted phenotypic indicators of response.1 2 As an example in a recent study by Szefler and colleagues it was found that baseline characteristics associated with a good response increase in forced expiratory volume in 1 second FEV1 15 to an inhaled corticosteroid ICS were high exhaled nitric oxide eNO level high b2 reversibility and a low FEV to forced vital capacity ratio.1 An exciting direction with regard to response to asthma therapy is the potential role of a patient s genetics in determining therapeutic response. Although initially the nomenclature associated with examining genetic polymorphisms GPs may seem like bringing meaning to alphabet soup it is quite likely that further advancement in our understanding of genetics will provide the clinician with a useful tool in patient care. In the case of cancer intensive research is ongoing regarding the evaluation of a patient s genetics to facilitate in making decisions regarding specific chemotherapy.3 It is hoped that similar genetic consideration will aid in the choice of class of asthma medication in the future. In this article we review each of the three major therapeutic classes of asthma therapy .