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Báo cáo y học: "Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma? | ORIGINAL ARTICLE Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma Sat Sharma MD FRCPC Adarsh Tailor MD FRCPC Richard Warrington MD PhD FRCPC and Mary Cheang M. Math We investigated the association between airway hyperresponsiveness AHR and obesity in adults referred for confirmation of asthma diagnosis. Data were analyzed for obesity class I body mass index BMI 30-34.9 kg m2 class II BMI 35-39.9 kg m2 and class III BMI 40 kg m2 . Of 861 subjects 401 demonstrated AHR the mean dose of methacholine was 4.16 2.55 mg mL. A significant association between obesity and AHR was evident for all subjects the odds ratio was 1.37 95 CI 1.02-1.82 p 5 .0317 . One unit of increased BMI 1 kg m2 was associated with a 3.1 increase in AHR risk 95 CI 1.01-1.05 p .005 . The odds ratio increased from 1.86 95 CI 1.27-1.76 p 5 .0012 for class I to 2.61 95 CI 1.48-4.60 p 5 .0006 for class III. Obesity was found to be associated with AHR and appears to be a risk factor for asthma. Key words airway hyperresponsiveness asthma obesity T ecently asthma and obesity have evolved into two major health concerns in developed countries.1 Over the past 20 years obesity among adults and children has risen significantly in the United States. The latest data from the National Center for Health Statistics show that 30 of US adults 20 years of age and older over 60 million people and 16 of children and teens age 6 to 19 years over 9 million young people are obese.2 In addition current data overwhelmingly document the existence of a worldwide asthma epidemic although individual studies remain controversial.3-6 The epidemic is thought primarily to involve persons with allergic asthma numerous diverse theories based on an immunopathologic understanding of the disease have recently emerged to explain this involvement. Thus it appears that during the past three decades the prevalence of both asthma and obesity has increased concurrently in Western countries .