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Báo cáo y học: "Assessment of epicutaneous testing of a monovalent Influenza A (H1N1) 2009 vaccine in egg allergic patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Assessment of epicutaneous testing of a monovalent Influenza A (H1N1) 2009 vaccine in egg allergic patients. | Pitt et al. Allergy Asthma Clinical Immunology 2011 7 3 http www.aacijournal.eom content 7 1 3 ALLERGY ASTHMA CLINICAL IMMUNOLOGY REVIEW Open Access Assessment of epicutaneous testing of a monovalent Influenza A H1N1 2009 vaccine in egg allergic patients Tracy Pitt Chrystyna Kalicinsky Richard Warrington Nestor Cisneros Abstract Background H1N1 is responsible for the first influenza pandemic in 41 years. In the fall of 2009 an H1N1 vaccine became available in Canada with the hopes of reducing the overall effect of the pandemic. The purpose of this study was to assess the safety of administering 2 different doses of a monovalent split virus 2009 H1N1 vaccine in egg allergic patients. Methods Patients were skin tested to the H1N1 vaccine in the outpatient paediatric and adult allergy and immunology clinics of the Health Sciences Centre and Children s Hospital of Winnipeg Manitoba Canada. Individuals 9 years of age were administered 1.88 lag s of hem-agglutinin antigen per 0.25 ml dose and individuals 9 years were administered 3.75 lag s of hemagglutinin antigen per 0.5 ml dose. Upon determination of a negative skin test the vaccine was administered with a 30 minute observation period. Results A total of 61 patients with egg allergy history of an allergic reaction to egg with either positive skin test or specific IgE to egg 0.35 Ku L were referred to our allergy clinics for skin testing to the H1N1 vaccine. 2 patients were excluded one did not have a skin prick test to the H1N1 vaccine only vaccine administration and the other passed an egg challenge during the study period. Ages ranged from 1 to 27 years mean 5.6 years . There were 41 69.5 males and 18 30.5 females. All but one patient with a history of egg allergy positive skin test to egg and or elevated specific IgE level to egg had negative skin tests to the H1N1 vaccine. The 58 patients with negative skin testing to the H1N1 vaccine were administered the vaccine and observed for 30 minutes post vaccination with