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Báo cáo y học: "Autoimmune response in cartilage-delivered peptides in a patient with osteoarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoimmune response in cartilage-delivered peptides in a patient with osteoarthritis. | Arthritis Research Therapy Vol 6 No 1 Nishioka Commentary Autoimmune response in cartilage-delivered peptides in a patient with osteoarthritis Kusuki Nishioka Arthritis Research Centre Institute of Medicine St Marianna University Kawasaki Japan Corresponding author Kusuki Nishioka e-mail k4nishi@marianna-u.ac.jp Received 7 Jul 2003 Accepted 22 Oct 2003 Published 5 Dec 2003 Arthritis Res Ther 2004 6 6-7 DOI 10.1186 ar1025 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Whatever the initiating factor of osteoarthritis OA the process ultimately unmasks the immunogenic determinants of chondrocytes proteoglycans and collagens which then triggers autoimmune reactions. Although the precise mechanism of the immune responses in the pathogenesis of OA requires further investigation here I postulate that the presence of autoimmunity to cartilage components has an important role in the process of cartilage degradation in OA. Current studies strongly suggest that a immunoregulatory therapeutic strategy should be established. Keywords cartilage chemokines components immunological intervention osteoarthritis Introduction My colleagues and I have recently reported several lines of evidence for a potential role of immunological intervention in the pathogenic process of osteoarthritis OA . In particular we have focused on the role of activated T cells 1 after an immunological response to the cartilage component 2-4 with activation by chemokines 5 6 . The background of this concept comes from a pathological feature of OA synovium. Although OA is generally accepted as one of the commonest degenerative joint disorders caused by biomechanical stress or aging instances of inflammatory features such as synovial effusion or swelling of affected joints have been reported. The accumulation of mononuclear cells in synovial fluid an increasing concentration of immunoglobulin and pathological findings of OA synovial tissue such as hyperplasia of synovial lining cells