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Báo cáo y học: "Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood. | Available online http arthritis-research.eom content 6 4 R295 Research article Patients with systemic lupus erythematosus have abnormally elevated Epstein-Barr virus load in blood Uk Yeol Moon1 Su Jin Park1 Sang Taek Oh1 Wan-Uk Kim2 Sung-Hwan Park2 Sang-Heon Lee2 Chul-Soo Cho2 Ho-Youn Kim2 Won-Keun Lee3 and Suk Kyeong Lee1 Research Institute of Immunobiology Catholic Research Institutes of Medical Science Catholic University of Korea Seoul Korea 2Department of Medicine The Center for Rheumatic Diseases Kangnam St. Mary s Hospital Seoul Korea 3Department of Biological Sciences Myongji University Yongin Kyunggi-do Korea Contributed equally Corresponding author Suk Kyeong Lee sukklee@cmc.cuk.ac.kr Received 4 Nov 2003 Revisions requested 5 Dec 2003 Revisions received 22 Mar 2004 Accepted 1 Apr 2004 Published 7 May 2004 Arthritis Res Ther 2004 6 R295-R302 DOI 10.1186 ar1181 2004 Moon et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract Various genetic and environmental factors appear to be involved in systemic lupus erythematosus SLE . Epstein-Barr virus EBV is among the environmental factors that are suspected of predisposing to SLE based on the characteristics of EBV itself and on sequence homologies between autoantigens and EBV antigens. In addition higher titers of anti-EBV antibodies and increased EBV seroconversion rates have been observed in SLE patients as compared with healthy control individuals. Serologic responses do not directly reflect EBV status within the body. Clarification of the precise status of EBV infection in SLE patients would help to improve our understanding of the role played by EBV in this disease. In the present study we determined EBV types in SLE patients n 66 and normal control individual n 63 by direct PCR analysis of mouthwash samples. .