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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus. | Available online http arthritis-research.eom content 6 4 169 Review Role of RUNX in autoimmune diseases linking rheumatoid arthritis psoriasis and lupus Marta E Alarcón-Riquelme Department of Genetics and Pathology Rudbeck Laboratory University of Uppsala Uppsala Sweden Corresponding author Marta E Alarcón-Riquelme marta.alarcon@genpat.uu.se Received 22 Mar 2004 Accepted 24 May 2004 Published 21 Jun 2004 Arthritis Res Ther 2004 6 169-173 DOI 10.1186 ar1203 2004 BioMed Central Ltd Abstract Recent studies investigating the genetic susceptibility of systemic lupus erythematosus rheumatoid arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of autoimmune disease. A new pathway of disease pathogenesis opens new avenues of research with thousands of questions that remain to be answered. In this review I attempt to propose how the RUNX proteins might be involved in these diseases and review current knowledge on this very interesting trio of transcription factors that was previously only suspected to be involved in cancer. Keywords autoimmunity repression runt-domain susceptibility transcription Introduction The study of the genetics of complex diseases is now advancing rapidly as new genes are being discovered that are involved in susceptibility for a variety of diseases. However more impressive is the fact that the identification of the genes and the polymorphisms involved in susceptibility is opening new avenues of study. The best example at hand is the recent identification of a polymorphism in the PDCD1 programmed cell death 1 gene as a susceptibility factor for systemic lupus erythematosus coding for the immunoreceptor PD-1 1 . The polymorphism identified named PD1.3 and whose allele A is strongly associated with the disease is so far the only polymorphism within the PDCD1 gene that can provide a functional explanation for the susceptibility related to this gene. Furthermore the same allele A was associated to diabetes type