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báo cáo khoa học: "The association of fish consumption with bladder cancer risk: A meta-analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The association of fish consumption with bladder cancer risk: A meta-analysis | Li et al. World Journal of Surgical Oncology 2011 9 107 http www.wjso.eom content 9 1 107 7 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access The association of fish consumption with bladder cancer risk A meta-analysis Zhongyi Li Jianda Yu Qilong Miao Shuben Sun Lingjun Sun Houmen Yang and Liejun Hou Abstract Background The association between fish consumption and risk of bladder cancer has not been established yet. The results from epidemiological studies are inconsistent. Methods We conducted a meta-analysis of cohort and case-control studies on the relationship between fish intake and bladder cancer. We quantified associations with bladder cancer using meta-analysis of relative risk associated to the highest versus the lowest category offish intake using random effect models. Heterogeneity among studies was examined using Q and I1 2 statistics. Publication bias was assessed using the Begg s funnel plot. Results Five cohort and 9 case-control studies were eligible for inclusion. The combined relative risk showed that fish consumption was negatively but not significantly associated with a decreased risk of bladder cancer relative risk 0.86 95 confidence interval 0.61-1.12 . In subgroup analyses there was no evidence that study design geographical region case sample size or exposure assessment substantially influenced the estimate of effects. Conclusion The overall current literature on fish consumption and the risk of bladder cancer suggested no association. Because of the limited number of studies further well-designed prospective studies are needed to explore the effect of fish on bladder cancer. Keywords Bladder neoplasms Diet Fish Meta-analysis Prevention 1. Background Bladder cancer is the second most common urologic malignancy and the seventh most common cancer in men. It has been estimated that 386 300 patients are newly diagnosed with bladder cancer worldwide in 2008 and approximately 150 200 patients were expected to die of it 1 . Depending on its .