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Báo cáo khoa học: "The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer | Kemik et al. World Journal of Surgical Oncology 2010 8 85 http www.wjso.eom content 8 1 85 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access The relationship among acute-phase response proteins cytokines and hormones in cachectic patients with colon cancer 1 A 1 2 1 r- n 3 4 Ozgur Kemik Aziz Sumer Ahu Sarbay Kemik Ismail Hasirci Sevim Purisa Ahmet Cumhur Dulger Baris Demiriz5 Sefa Tuzun6 Abstract Backgraund Acute-phase response proteins APRP cytokines and hormones have been claimed to be an independent prognostic factor of malignancies however the basis for their association with prognosis remains unexplained. We suggest that in colon malignancies as similar to pancreatic and lung cancers changes in APRP are associated with angiogenesis. Methods C-reactive protein CRP albumin IL-1a IL-1P IL-6 IL-8 IL-10 TNF-a midkine VEGF-A VEGF-C leptin adiponectin and ghrelin serum levels are studied in 126 colon cancer patients and 36 healthy subjects. Results We found statistically significant difference and correlations between two groups. We found significantly higher serum CRP IL-1a IL-1P IL-6 IL-8 IL-10 TNF-a VEGF-A VEGF-C and leptin concentrations in patients relative to controls p 0.001 . We found lower levels of the serum albumin midkine adiponectin and ghrelin in patients compared to control subjects p 0.001 . Conclusions Cachexia in patients with colon cancers is associated with changes in APRP cytokines and hormone concentrations. These biomarkers and cachexia together have a direct relationship with accelerated angiogenesis. This may lead to a connection between the outcomes in malignancies and the biomarkers. Introduction Cachexia due to cancer is one of the most frequent features of malignancy 1 it accounts up to 30-50 of cancer-related deaths in gastrointestinal tract malignancies 2 . Cachexia due to cancer is a complex metabolic disorder including loss of adipose tissue due to lipolysis loss of skeletal muscle mass elevation of resting energy consumption .