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Báo cáo y học: "Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. | Available online http arthritis-research.eom content 7 3 R503 Research article Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption David A Young1 3 Rachel L Lakey2 Caroline J Pennington1 Debra Jones2 Lara Kevorkian1 Dylan R Edwards1 Timothy E Cawston2 and Ian M Clark1 School of Biological Sciences University of East Anglia Norwich UK 2Department of Rheumatology University of Newcastle-upon-Tyne Newcastle-upon-Tyne UK 3Department of Rheumatology University of Newcastle-upon-Tyne Newcastle-upon-Tyne UK Corresponding author Ian M Clark i.clark@uea.ac.uk Received 11 Nov 2004 Revisions requested 23 Dec 2004 Revisions received 7 Jan 2005 Accepted 25 Jan 2005 Published 22 Feb 2005 Arthritis Research Therapy 2005 7 R503-R512 DOI 10.11 86 ar1 702 This article is online at http arthritis-research.com content 7 3 R503 2005 Young et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families the matrix metalloproteinases MMPs are responsible for cartilage collagen breakdown and enzymes from the ADAMTS a disintegrin and metalloproteinase domain with thrombospondin motifs family mediate cartilage aggrecan loss. Many genes subject to transcriptional control are regulated at least in part by modifications to chromatin including acetylation of histones. The aim of this study was to examine the impact of histone deacetylase HDAC inhibitors on the expression of metalloproteinase genes in chondrocytes and to explore the potential of these inhibitors as chondroprotective agents. The effects of HDAC inhibitors on cartilage degradation were assessed using a bovine nasal .