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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control. | Available online http arthritis-research.eom content 7 4 R817 Research article Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control Rille Pullerits1 Maria Bokarewa1 Leif Dahlberg2 and Andrej Tarkowski1 Department of Rheumatology and Inflammation Research University of Goteborg Goteborg Sweden 2Joint and Soft Tissue Unit Department of Clinical Sciences Lund University Department of Orthopaedics Malmo University Hospital Malmo Sweden Corresponding author Rille Pullerits rille.pullerits@rheuma.gu.se Received 8 Dec 2004 Revisions requested 6 Jan 2005 Revisions received 4 Mar 2005 Accepted 16 Mar 2005 Published 25 Apr 2005 Arthritis Research Therapy 2005 7 R817-R824 DOI 10.11 86 ar1 749 This article is online at http arthritis-research.com content 7 4 R817 2005 Pullerits et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract The receptor for advanced glycation end products RAGE is a member of the immunoglobulin superfamily being expressed as a cell surface molecule and binding a variety of ligands. One of these ligands is high-mobility group box chromosomal protein 1 a potent proinflammatory cytokine expression of which is increased in synovial tissue and in synovial fluid of rheumatoid arthritis RA patients. The interaction of high-mobility group box chromosomal protein 1 with cell-surface RAGE leads to an inflammatory response. In contrast the presence of soluble RAGE sRAGE may abrogate cellular activation since the ligand is bound prior to interaction with the surface receptor. Our aim was to analyse to what extent sRAGE is present in patients with chronic joint inflammation RA as compared with patients with .