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Báo cáo y học: " Aging, osteoarthritis and transforming growth factor-β signaling in cartilage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:β Aging, osteoarthritis and transforming growth factor-β signaling in cartilage. | Available online http arthritis-research.eom content 8 1 101 Commentary Aging osteoarthritis and transforming growth factor-p signaling in cartilage A Hari Reddi Lawrence J Ellison Center for Tissue Regeneration University of California Davis School of Medicine Sacramento CA 95817 USA Corresponding author A Hari Reddi ahreddi@ucdavis.edu Published 28 November 2005 Arthritis Research Therapy 2006 8 101 doi 10.1186 ar1858 This article is online at http arthritis-research.com content 8 1 101 2005 BioMed Central Ltd See related research by Davidson et al. in issue 7.6 http arthritis-research.com content 7 6 R1338 Abstract Osteoarthritis is a common malady of the musculoskeletal system affecting the articular cartilage. The increased frequency of osteoarthritis with aging indicates the complex etiology of this disease which includes pathophysiology and joint stability including biomechanics. The balance between anabolic morphogens and growth factors and catabolic cytokines is at the crux of the problem of osteoarthritis. One such signal is transforming growth factor-p TGF-p . The impaired TGF-p signaling has been identified as a culprit in old mice in a recent article in this journal. This commentary places this discovery in the context of anabolic and catabolic signals and articular cartilage homeostasis in the joint. It is common knowledge that with aging one confronts the generally inevitable pain in the joints that limits mobility as a result of osteoarthritis. Osteoarthritis is characterized by articular cartilage damage and the resultant repair response including osteophyte formation and joint capsule thickening. The etiology of osteoarthritis remains unknown. At steady state the homeostasis and response of articular cartilage is determined by the exquisite control of the cells and extracellular matrix by anabolic morphogens and catabolic cytokines 1 . The aim of this commentary is to place in context a recent article in this journal of anabolic growth factor .