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Báo cáo y học: "Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. | Available online http arthritis-research.eom content 8 1 R15 Research article Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis Sarah L Jongbloed1 M Cristina Lebre2 Alasdair R Fraser1 J Alastair Gracie1 Roger D Sturrock1 Paul P Tak2 and Iain B Mclnnes1 Division of Immunology Infection and Inflammation 10 Alexandra Parade Glasgow G31 2ER UK 2Director Academic Medical Center Division of Clinical Immunology and Rheumatology Academic Medical Center University of Amsterdam F4-218 P.O. Box 22700 1100 DE Amsterdam The Netherlands Contributed equally Corresponding author Iain B McInnes ibmi1w@clinmed.gla.ac.uk Received 13 Jun 2005 Revisions requested 26 Jul 2005 Revisions received 20 Oct 2005 Accepted 9 Nov 2005 Published 16 Dec 2005 Arthritis Research Therapy 2006 8 R15 doi 10.1186 ar1 864 This article is online at http arthritis-research.com content 8 1 R15 2005 Jongbloed et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Dendritic cells DCs comprise heterogeneous subsets of professional antigen-presenting cells linking innate and adaptive immunity. Analysis of DC subsets has been hampered by a lack of specific DC markers and reliable quantitation assays. We characterised the immunophenotype and functional characteristics of psoriatic arthritis PsA -derived and rheumatoid arthritis RA -derived myeloid DCs mDCs and plasmacytoid DCs pDCs to evaluate their potential role in arthritis. Circulating peripheral blood PB pDC numbers were significantly reduced in PsA patients P 0.0098 and RA patients P 0.0194 and mDCs were significantly reduced in RA patients P 0.0086 compared with healthy controls. The number of circulating mDCs in RA PB was .