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Báo cáo y học: "Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production. | Available online http arthritis-research.eom content 8 4 R88 Research article Interleukin-15 and interferon-Y participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production Isidoro González-Álvaro1 Carmen Dominguez-Jimenez1 Ana M Ortiz1 Vanessa Nunez-Gonzalez1 Pedro Roda-Navarro2 3 Elena Fernandez-Ruiz2 David Sancho4 and Francisco Sanchez-Madrid4 Open Access 1Servicio de Reumatologia Hospital Universitario de la Princesa c Diego de León 62 28006 Madrid Spain 2Unidad de Biologia Molecular Hospital Universitario de la Princesa c Diego de León 62 28006 Madrid Spain 3Current address Department of Pathology University of Cambridge Tennis Court Road Cambridge CB2 1QP UK 4Servicio de Inmunologia Hospital Universitario de la Princesa c Diego de León 62 28006 Madrid Spain Corresponding author Francisco Sanchez-Madrid fsanchez.hlpr@salud.madrid.org Received 7 Mar 2006 Revisions requested 23 Mar 2006 Revisions received 31 Mar 2006 Accepted 11 Apr 2006 Published 9 May 2006 Arthritis Research Therapy 2006 8 R88 doi 10.1186 ar1955 This article is online at http arthritis-research.com content 8 4 R88 2006 González-Álvaro et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have characterized the lymphocyte subset and the receptor molecules involved in inducing the secretion of TNF by monocytic cells in vitro. The TNF secreted by monocytic cells was measured when they were co-cultured with either resting or IL-15-stimulated lymphocytes T cells B cells or natural killer NK cells isolated from the peripheral blood of healthy subjects and from the synovial fluid from patients with inflammatory arthropathies. Co-culture with IL-15-activated peripheral blood or synovial .