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Báo cáo y học: " Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine. | Available online http arthritis-research.eom content 8 5 R141 Research article Preventing autoimmune arthritis using antigen-specific immature dendritic cells a novel tolerogenic vaccine Igor Popov1 Mu Li1 Xiufen Zheng1 Hongtao San1 Xusheng Zhang1 Thomas E Ichim1 Motohiko Suzuki1 Biao Feng1 Costin Vladau1 Robert Zhong1 2 3 4 Bertha Garcia1 3 Gill Strejan1 Robert D Inman5 and Wei-Ping Min1 2 3 4 Open Access Department of Surgery Microbiology and Immunology and Pathology London Health Science Centre London Canada 2Multi-Organ Transplant Program London Health Science Centre London Canada 3Immunology and Transplantation Lawson Health Research Institute London Canada 4Robarts Research Institute London Canada 5Division of Rheumatology Department of Medicine Toronto Western Hospital University Health Network Toronto Canada Corresponding author Wei-Ping Min mweiping@uwo.ca Received 9 Mar 2006 Revisions requested 11 Apr 2006 Revisions received 18 Jul 2006 Accepted 15 Aug 2006 Published 15 Aug 2006 Arthritis Research Therapy 2006 8 R141 doi 10.1186 ar2031 This article is online at http arthritis-research.com content 8 5 R141 2006 Popov et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Conventional treatments for autoimmune diseases have relied heavily on nonspecific immune suppressants which possess a variety of adverse effects without inhibiting the autoimmune process in a specific manner. In the present study we demonstrate the effectiveness of antigen-specific maturationresistant tolerogenic dendritic cells DC in suppressing collagen-induced arthritis a murine model of rheumatoid arthritis. Treatment of DC progenitors with the NF-kB inhibiting agent LF 15-0195 LF resulted in a population of tolerogenic DC that are .