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Báo cáo y học: "TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. | Available online http arthritis-research.eom content 8 5 R146 Research article TWEAK Fn14 interaction regulates RANTES production BMP-2-induced differentiation and RANKL expression in mouse osteoblastic MC3T3-E1 cells Takashi Ando1 Jiro Ichikawa2 Masanori Wako2 Kyosuke Hatsushika1 Yoshiyuki Watanabe2 Michitomo Sakuma2 Kachio Tasaka1 Hideoki Ogawa3 Yoshiki Hamada2 Hideo Yagita4 and Atsuhito Nakao1 3 Open Access 1 Department of Immunology Faculty of Medicine University of Yamanashi 1110 Shimokato Chuo Yamanashi 409-3898 Japan 2Department of Orthopedic Surgery Faculty of Medicine University of Yamanashi 1110 Shimokato Chuo Yamanashi 409-3898 Japan 3Atopy Research Center Juntendo University School of Medicine 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan 4Department of Immunology Juntendo University School of Medicine 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan Contributed equally Corresponding author Atsuhito Nakao anakao@yamanashi.ac.jp Received 17 Apr 2006 Revisions requested 19 May 2006 Revisions received 13 Jul 2006 Accepted 1 Sep 2006 Published 1 Sep 2006 Arthritis Research Therapy 2006 8 R146 doi 10.1186 ar2038 This article is online at http arthritis-research.com content 8 5 R146 2006 Ando et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Tumour necrosis factor TNF -like weak inducer of apoptosis TWEAK a member of the TNF family is a multifunctional cytokine that regulates cell growth migration and survival principally through a TWEAK receptor fibroblast growth factorinducible 14 Fn14 . However its physiological roles in bone are largely unknown. We herein report various effects of TWEAK on mouse osteoblastic MC3T3-E1 cells. MC3T3-E1 cells expressed Fn14 and produced RANTES regulated upon activation healthy T