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Báo cáo khoa học: "Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer. | Kitayama etal. Radiation Oncology 2010 5 47 http www.ro-journal.eom content 5 1 47 RADIATION ONCOLOGY SHORT REPORT Open Access Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer Joji Kitayama Koji Yasuda Kazushige Kawai Eiji Sunami and Hirokazu Nagawa Abstract Although neoadjuvant chemoradiotherapy CRT is the standard treatment for advanced rectal cancer RC markers to predict the treatment response have not been fully established. In 73 patients with advanced RC who underwent CRT in a neoadjuvant setting we retrospectively examined the associations between the clinical effects of CRT and blood cell counts before and after CRT. Clinical or pathological complete response CR was observed in 10 14 cases. The CR rate correlated significantly with the size and the circumferential extent of the tumor. Hemoglobin level white blood cell WBC count and platelet count before CRT did not show a significant difference between CR and non-CR cases. Interestingly however lymphocyte ratio in WBC was significantly higher p 0.020 while neutrophil ratio tended to be lower p 0.099 in CR cases which was shown to be an independent association by multivariate analysis. When all the blood data obtained in the entire treatment period were evaluated circulating lymphocyte count was most markedly decreased in the CRT period and gradually recovered by the time of surgery while the numbers of neutrophils and monocytes were comparatively stable. Moreover the lymphocyte percentage in samples obtained from CR patients was maintained at a relatively higher level than that from non-CR patients. Since tumor shrinkage is known to be dependent not only on the characteristics of tumor cells but also on various host conditions our data raise the possibility that a lymphocyte-mediated immune reaction may have a positive role in achieving complete eradication of tumor cells. Maintenance of circulating lymphocyte number may