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Báo cáo khoa học: "Feasibility study of volumetric modulated arc therapy for the treatment of retroperitoneal sarcomas"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Feasibility study of volumetric modulated arc therapy for the treatment of retroperitoneal sarcomas. | Llacer-Moscardo et al. Radiation Oncology 2010 5 83 http www.ro-journal.eom content 5 1 83 RADIATION ONCOLOGY RESEARCH Open Access Feasibility study of volumetric modulated arc therapy for the treatment of retroperitoneal sarcomas Carmen Llacer-Moscardo1 Frangois Quenet2 David Azria1 Pascal Fenoglietto1 Abstract Background Radiotherapy for retroperitoneal sarcomas remains controversial and a technical challenge considering the threshold of contiguous critical organs tolerance. We performed consecutive RapidArc dosimetric plans in preoperative or postoperative setting. Methods A dosimetric study was carried out from six preoperative group A and four postoperative group B CT-scans performed in 7 patients. Prescribed dose was 45 and 50 Gy for groups A and B respectively. The planning target volume PTV was defined as the clinical target volume CTV plus 5 mm. The CTV encompassed the gross tumor volume GTV plus 10 mm or the tumoral bed. The dosimetric plans were optimized on a RapidArc Eclipse console using the progressive resolution algorithm PRO version 8.8. Normalization method allowed the coverage of 99 of the PTV by 95 of the dose. Results Mean PTV were 2318.5 2223.9 cc range 348-6198 cc and 698.3 216.6 cc range 463 -933 cc for groups A and B respectively. Plans were optimized for single arcs in group B and for single or two arcs in group A. The contralateral kidney volume receiving 5 Gy V5Gy was 21.5 23.3 range 0-55 and 3.1 2.6 range 07.3 for groups A and B respectively. The mean dose received by 1 of the kidney D1 was 5.6 2.4 Gy range 3.6 -7.6 Gy for group A and 5.4 0.7 Gy range 4.3-6 Gy for group B. The volume of small bowel excluding the PTV small bowel-PTV that received 40 Gy and 30 Gy V40Gy and V30Gy in group A were 7.5 4.4 range 5.414.1 and 18.5 7.1 range 10-30.4 respectively. In group B small bowel-PTV V40Gy and V30Gy were 4.7 3.3 range 3.3-8 and 21.6 7.5 range 9.4-30 respectively. In a second step we treated two patients in the postoperative group. .