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Báo cáo y học: "Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis Peter Ahnert and Holger Kirsten"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis Peter Ahnert and Holger Kirsten. | Available online http arthritis-research.eom content 9 5 108 Editorial Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis Peter Ahnert and Holger Kirsten Universitat Leipzig IMISE IKIT BBZ Johannisallee 30 04109 Leipzig Germany Corresponding author Peter Ahnert peter.ahnert@gmx.net Published 31 October 2007 Arthritis Research Therapy 2007 9 108 doi 10.1186 ar2313 This article is online at http arthritis-researeh.eom eontent 9 5 108 2007 BioMed Central Ltd See related research article by Jacq et al. http arthritis-research.com content 9 4 R63 and related letter by likuni et al. http arthritis-research.com content 9 5 405 Abstract Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis RA Jacq and colleagues present a family-based multi-stage candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA C-containing genotypes odds ratio 1.94 confidence interval 1.3 to 2.9 P 0.002 . Support comes from a recent genome-wide study which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis verification in further studies and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease. Jacq and colleagues 1 have presented a candidate gene association study in French and European Caucasian populations showing evidence that the rs3738919-C variant major allele of the gene ITGAV may be associated with rheumatoid arthritis RA with an overall odds ratio OR for C-containing genotypes of 1.94 and a 95 confidence interval CI of 1.3 to 2.9 P 0.002 . In the light of difficulties surrounding studies on candidate gene associations how did the authors arrive at this result what needs to be done further and how does the discovery fit in the quest