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Báo cáo y học: "Atherosclerotic disease is increased in recent-onset rheumatoid arthritis: a critical role for inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Atherosclerotic disease is increased in recent-onset rheumatoid arthritis: a critical role for inflammation. | Available online http arthritis-research.eom content 9 6 R116 Research article Atherosclerotic disease is increased in recent-onset rheumatoid arthritis a critical role for inflammation Suad Hannawi1 Brian Haluska2 Thomas H Marwick2 and Ranjeny Thomas3 Centre for Immunology and Cancer Research University of Queensland Princess Alexandra Hospital Brisbane QLD 4102 Australia 2Department of Medicine University of Queensland Princess Alexandra Hospital Brisbane QLD 4102 Australia 3Diamantina Institute for Cancer Immunology and Metabolic Medicine University of Queensland Princess Alexandra Hospital Brisbane QLD 4102 Australia Contributed equally Corresponding author Ranjeny Thomas r.thomas1@uq.edu.au Received 10 May 2007 Revisions requested 2 Jul 2007 Revisions received 16 Oct 2007 Accepted 6 Nov 2007 Published 6 Nov 2007 Arthritis Research Therapy 2007 9 R116 doi 10.1186 ar2323 This article is online at http arthritis-research.com content 9 6 R116 2007 Hannawi et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 20 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Rheumatoid arthritis RA patients have increased mortality and morbidity as a result of cardiovascular and cerebrovascular disease. What is not clear however is either how early accelerated atherosclerosis begins in RA or how soon risk factors must be rigorously controlled. Furthermore given the strong relationship of vascular disease to RA mortality and of inflammation to the accelerated atherosclerosis associated with RA it is important to evaluate indices that could serially and noninvasively quantify atherosclerotic disease in RA patients. The carotid intima-media thickness cIMT and plaque measured by ultrasound correlate closely with direct measurement of the local and systemic atherosclerotic