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Báo cáo y học: " New insights in understanding the pathogenesis of spondyloarthropathies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: New insights in understanding the pathogenesis of spondyloarthropathies. | van der Horst-Bruinsma and Crusius Arthritis Research Therapy 2010 12 102 http arthritis-research.eom content 12 1 102 EDITORIAL L_ New insights in understanding the pathogenesis of spondyloarthropathies Irene E van der Horst-Bruinsma 1 and J Bart A Crusius2 See related research by Sharma etal. http arthritis-research.Com content 11 6 R168 Abstract Spondyloarthropathies SpA are characterised by dysregulation of the inflammatory processes and bone metabolism which may be clarified by gene expression profiles. Sharma and colleagues showed associations of axial SpA with the innate immune system inflammation markers and markers of bone remodeling. Drawbacks of this study are the patient selection based on uveitis which limits the extrapolation of these data and the racial difference between index cases and controls which contributes to differences in gene expression. Nevertheless this study provides a direction for unraveling the intriguing balance between inflammation and ossification in ankylosing spondylitis. Gene expression profiles may clarify our understanding of the pathophysiology of disease and by redefining pathways of inflammation may offer new alternatives for treatment of chronic diseases such as the spondyloarthropathies SpA . If the expression profiles are specific for the disease or for a particular subgroup of patients the data may generate biomarkers to classify the disease and define the stage of the inflammatory process. Genome-wide RNA expression analysis will thus lead to new insights in the pathogenesis of heterogeneous diseases such as SpA. These studies are expensive and powerful statistical approaches are necessary for achieving reproducible results. The potential gains however are of great clinical importance. Attention should be given to the selection of patients to the state of the inflammatory process and to the possible effect of Correspondence IE.vanderHorst@vumc.nl department of Rheumatology VU University Medical Centre PO Box