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Báo cáo y học: "he enigma that is the nucleus pulposus cell: the search goes on"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: he enigma that is the nucleus pulposus cell: the search goes on. | Erwin Arthritis Research Therapy 2010 12 118 http arthritis-research.eom content 12 3 118 EDITORIAL L_ The enigma that is the nucleus pulposus cell the search goes on W Mark Erwin See related research by Gilson etal. http arthritis-research.eom content 12 1 R24 Abstract The development of an effective treatment for degenerative disc disease has been hampered for many years by what seems a fundamental problem what exactly defines a nucleus pulposus NP cell The paper by Gilson and colleagues elegantly re-opens the debate concerning the lineage and identity of NP cells that are alike yet different from chondrocytes. As we pursue novel investigations and treatment strategies for degenerative disc disease how do we isolate these unique cells and what is the role of the primordial notochordal cell that may well linger within the NP far longer and perhaps in a different phenotypic appearance than previously thought The paper by Gilson and colleagues that is the subject of the present editorial presents compelling data concerning the heterogeneity of the cells of the NP and their origin development maturation and function. A recent issue of Arthritis Research and Th erapy contains a report by Gilson and colleagues describing their investigation of the differential cell surface marker expression found in samples of bovine intervertebral disc IVD and articular chondrocytes 1 . This report raises interesting questions about the identity of the residents within the nucleus pulposus NP and has broad implications with respect to regenerative medicine and tissue engineering of the IVD. A recent search of PubMed using the search term tissue engineering and intervertebral disc returned 263 hits with the oldest publication dating to 1989. Although investigators have clearly been interested in developing a biological treatment for degenerative disc disease for Correspondence mark.erwin@utoronto.ca The Spine Programme Division of Orthopaedic Surgery Toronto Western Hospital .