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Báo cáo y học: " Variability in the precursor proteins of collagen I and III in different stages of COPD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Variability in the precursor proteins of collagen I and III in different stages of COPD. | Harju et al. Respiratory Research 2010 11 165 http respiratory-research.eom content 11 1 165 RESPIRATORY RESEARCH RESEARCH Open Access Variability in the precursor proteins of collagen I and III in different stages of COPD Tdrtti I I Inrli 1 2 ir iUzci I l lnm H3 PSSUzci4 l .iic .i .ilrnd l i. i5 II lU .i Plctdl6 Piirt .i Itaartaanahrs 1 2 lerttu Hdrju vuokko L Klnnuld Pddvo rddkko Kdlsd Sdll I lei Iklvl Juild Rlstell Rllttd Kddlleel Idl 1U Abstract Background Levels of precursor protelns of colldgen I dnd III dre lncredsed ln flbrotlc pulmondry dlsedses. Thls study determlned whether the expresslon of precursors of type I dnd III colldgen protelns would be lncredsed ln smdll dnd ldrge dlrwdys of COPD pdtlents ln vdrlous stdges of the dlsedse reflectlng flbrogenesls. Methods The levels of precursor protelns of colldgen I dnd III were studled by lmmunohlstochemlstry dnd qudntlfled by lmdge dndlysls ln lung tlssue of 16 non-smokers 20 smokers wlth normdl lung function 20 smokers wlth stdge I-II COPD dnd 8 ex-smokers wlth stdge IV COPD. Results In ldrge dlrwdys the subeplthelldl ldyer whlch wds posltlve for precursor protelns of colldgen I dnd III wds thlcker ln smokers dnd ln stdge I-II COPD compdred to non-smokers. Ldrge dlrwdys ln stdge IV COPD showed reduced expresslon of precursor proteln of colldgen I whereds precursor of colldgen III wds lncredsed. The dmount of precursor proteln of colldgen III wds lncredsed ln smdll dlrwdys of smokers dnd stdge I-II COPD but reduced ln stdge IV COPD. Conclusions Precursor protelns of colldgen I dnd III revedled dlfferent expresslon proflles ln ldrge dnd smdll dlrwdys ln vdrlous stdges of COPD. Smoklng enhdnced expresslon of both precursors ln ldrge dlrwdys wlth d posltlve correldtlon wlth pdck-yedrs. Background Repeated exposure to cigarette smoke induces persistent inflammation and oxidative stress in lungs which leads to damage of lung parenchyma and airways and a process of continuous repair and remodeling 1 . It is not .