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Báo cáo y học: " Increase of nitrosative stress in patients with eosinophilic pneumonia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Increase of nitrosative stress in patients with eosinophilic pneumonia. | Furukawa et al. Respiratory Research 2011 12 81 http respiratory-research.eom content 12 1 81 RESPIRATORY RESEARCH RESEARCH Open Access Increase of nitrosative stress in patients with eosinophilic pneumonia 1 1 1 11 1 Kanako Furukawa Hisatoshi Sugiura Kazuto Matsunaga Tomohiro Ichikawa Akira Koarai Tsunahiko Hirano 1 1 1 1 2 Satoru Yanagisawa Yoshiaki Minakata Keiichiro Akamatsu Masae Kanda Manabu Nishigai and Masakazu Ichinose 1 Abstract Background Exhaled nitric oxide NO production is increased in asthma and reflects the degree of airway inflammation. The alveolar NO concentration Calv in interstitial pneumonia is reported to be increased. However it remains unknown whether NO production is increased and nitrosative stress occurs in eosinophilic pneumonia EP . We hypothesized that nitrosative stress markers including Calv inducible type of NO synthase iNOS and 3-nitrotyrosine 3-NT are upregulated in EP. Methods Exhaled NO including fractional exhaled NO FENO and Calv was measured in ten healthy subjects 13 patients with idiopathic pulmonary fibrosis IPF and 13 patients with EP. iNOS expression and 3-NT formation were assessed by immunocytochemistory in BALf cells. The exhaled NO lung function and systemic inflammatory markers of the EP patients were investigated after corticosteroid treatment for 4 weeks. Results The Calv levels in the EP group 14.4 2.0 ppb were significantly higher than those in the healthy subjects 5.1 0.6 ppb p 0.01 and the IPF groups 6.3 0.6 ppb p 0.01 as well as the FENO and the corrected Calv levels all p 0.01 . More iNOS and 3-NT positive cells were observed in the EP group compared to the healthy subject and IPF patient. The Calv levels had significant positive correlations with both iNOS r 0.858 p 0.05 and 3-NT positive cells r 0.924 p 0.01 . Corticosteroid treatment significantly reduced both the FENO p 0.05 and the Calv levels p 0.01 . The magnitude of reduction in the Calv levels had a significant positive correlation with the .